|
Symbol Name ID |
Sod2
superoxide dismutase 2, mitochondrial MGI:98352 |
| * | Aspects of the system are reported to show a normal phenotype. |
| ! | Indicates phenotype varies with strain background. |
| Darker colors indicate more annotations |
| Human Phenotypes | Gastrointestinal hemorrhage |
Retinal hemorrhage |
Cerebral hemorrhage |
Bruising susceptibility |
Central retinal vessel vascular tortuosity |
Abnormal cardiovascular system morphology |
Abnormal heart morphology |
Abnormal endocardium morphology |
Mitral valve prolapse |
Restrictive cardiomyopathy |
Pericarditis |
Coronary artery atherosclerosis |
Medial calcification of large arteries |
Medial calcification of medium-sized arteries |
Arterial stenosis |
Premature occlusive vascular stenosis |
Arteriosclerosis |
Atherosclerosis |
Accelerated atherosclerosis |
Vascular dilatation |
Abnormal cerebral vascular morphology |
Stroke |
Vascular granular osmiophilic material deposition |
Mitral stenosis |
Hypertension |
Renovascular hypertension |
Weak pulse |
Intermittent claudication |
Raynaud phenomenon |
Arrhythmia |
Sudden cardiac death |
Angina pectoris |
Congestive heart failure |
Lymphadenopathy |
Splenomegaly |
Hepatosplenomegaly |
Telangiectasia of the skin |
| Disease(s) Associated with SOD2 | |||||||||||||||||||||||||||||||||||||
| Leber hereditary optic neuropathy | |||||||||||||||||||||||||||||||||||||
| multiple myeloma | |||||||||||||||||||||||||||||||||||||
| neuronal ceroid lipofuscinosis | |||||||||||||||||||||||||||||||||||||
| pancreatic cancer | |||||||||||||||||||||||||||||||||||||
| pseudoxanthoma elasticum | |||||||||||||||||||||||||||||||||||||
| systemic lupus erythematosus |
| Mouse Phenotypes | cardiovascular system phenotype |
abnormal retina vasculature morphology |
abnormal cardiac muscle tissue morphology |
increased cardiac muscle glycogen level |
abnormal myocardium layer morphology |
abnormal myocardial fiber morphology |
myocardial fiber degeneration |
myocardial fiber disarray |
cardiac muscle necrosis |
increased heart weight |
enlarged heart |
cardiac hypertrophy |
abnormal heart left ventricle morphology |
dilated heart left ventricle |
thin ventricular wall |
dilated heart ventricle |
dilated heart right ventricle |
cardiac fibrosis |
cardiac interstitial fibrosis |
dilated heart |
dilated cardiomyopathy |
retina hemorrhage |
decreased cardiac muscle contractility |
abnormal heart echocardiography feature |
increased cardiomyocyte apoptosis |
congestive heart failure |
|
| Availability | Mouse Genotype | ||||||||||||||||||||||||||
| Sod2tm1.1Kskk/Sod2tm1.1Kskk | |||||||||||||||||||||||||||
| Sod2tm1Cje/Sod2tm1Cje | ! | ! | |||||||||||||||||||||||||
| Sod2tm1Leb/Sod2tm1Leb | |||||||||||||||||||||||||||
| Sod2tm1.1Kskk/Sod2+ | |||||||||||||||||||||||||||
| Sod2tm1Kskk/Sod2tm1Kskk Tg(BEST1-rtTA,tetO-cre)1Yzl/0 (conditional) |
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| Sod2tm1Shs/Sod2tm1Shs Tg(Cdh16-cre)91Igr/0 (conditional) |
* | ||||||||||||||||||||||||||
| Sod2tm1Shs/Sod2tm1Shs Tg(Ckmm-cre)5Khn/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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